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Seattle Proteome Center (SPC)
Proteomics Center at the Institute for Systems Biology

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Proteomic standards

About the Center:
   Overview
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   HTPF WG
   Macrophage WG
   FAIMS
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   Protocols
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    Software course
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INVESTIGATORS BY PROJECT FOCUS

Biology Working Groups

MACROPHAGE WORKING GROUP
Name Affiliation Project focus
Alan Aderem ISB Macrophage secreted proteome
Elizabeth Gold UW, Cardiology/ISB Statins and macrophage activation
Peter Gough UW, Pathology Macrophage shed proteome
Katy Kennedy ISB Macrophage secreted proteome
Elaine Raines UW, Pathology Macrophage shed proteome
Lynn Schnapp UW, Medicine/Pulmonary ARDS alveolar lavage fluid

DEVELOPMENT WORKING GROUP
Name Affiliation Project focus
Bob Eisenman FHCRC, Basic Science Myc oncogen function
Mark Groudine FHCRC, Basic Science Beta-globin locus & DNA binding proteins
Steve Hauschka UW, Biochemistry Cardiac-specific enhancer
Yuzuru Shiio FHCRC, Basic Science B Cell chromatin associated proteins
Chris Wilson UW, Immunology Epigenetic regulation in T cell development

SIGNALING WORKING GROUP
Name Affiliation Project focus
Joe Beavo UW, Pharmacology Phosphodiesterase in SMC proliferation
William Catterall UW, Pharmacology Calcium channel signaling in cardiac & vascular SMC
Hilary Coller FHCRC, Basic Science Quiescent v. proliferative lung fibroblast
John Glomset UW, Medicine/Biochemistry Membrane associated signaling complexes
John Harlan UW, Medicine/Hematology Endothelial apoptotic signaling complexes
Neil Nathanson UW, Pharmacology Agonist-induced receptor internalization
Jim Roberts FHCRC, Basic Science Quiescent v. proliferative lung fibroblast
Steve Schwartz UW, Pathology Death-associated protein complexes in macrophages
Dan Storm UW, Pharmacology Adenylate cyclase complexes & SMC proliferation
Zengui Xia UW, Pharmacology ERK5 protein complexes and cardiac hypertrophy

Technology Development Working Group

Name Affiliation Technology Module
Yong Chi ISB Selective isolation of phosphorylated peptides
Hookeun Lee ISB Separation science
Jeff Ranish ISB Protein complex analysis
Yu Lu ISB Separation science
Xiao-Jun Li ISB Software development
Mingliang Ye ISB Mass spectrometry development
Patrick Pedrioli ISB Protein expression
Jimmy Eng ISB Software development
Andrew Keller ISB Software development
Alex Nesvizhskii ISB Software development
Ning Zhang ISB Software development
Benno Schwikowski ISB Software development
Eric Deutsch ISB Database development

High Throughput Proteome Facility Staff

Name/Title Field of Study Role at SPC
David R. Goodlett,Ph.D.
Director of Proteomics
Senior Research Scientist
Chemistry
Biochemistry
Principle Investigator
Laboratory Manager
Director, Proteomics Facility
Eugene C. Yi, Ph.D.
Research Scientist
Chemistry
Biochemistry
MS Operator
Sample preparation
Method implementation
Hookeun Lee, Ph.D.
Research Scientist
Chemistry
Analytical Chemistry
MS Operator
Sample preparation
Method implementation
Jimmy Eng, M.S.
Senior Software Engineer
Electrical Engineering
Programmer
Collaborator Training
Wei Yan, Ph.D.
Research Scientist
Zoology
Biomolecular Chemistry
MS operator
Data analysis
Samuel Donohoe
Research Associate II
Cellular and Molecular Biology MS Operator
Sample preparation
Collaborator Training
Jinzhi (Jenny) Chen, Ph.D.
Postdoctoral Fellow
Chemistry
Analytical Chemistry
MS Operator
Sample preparation
Method implementation

Integrated Systems Biology Working Group

Name Affiliation Technology Module
Ruedi Aebersold ISB Quantitative proteomics
Anne-Claude Gingras ISB Systematic perturbation of mammalian cells
Alan Aderem ISB Macrophage biology & single cell assays
Elaine Raines UW, Pathology Macrophage biology/in vivo mouse modeling
Tim Galitski ISB Computational pathway modeling
Benno Schwikowski ISB Computational pathway modeling




Proteomics Center @ ISB