In addition to dissemination through applied projects that are part of the
Biology Working Groups, technologies developed in the Center will be
disseminated through technology transfer, training and commercialization. SPC
will train personnel from academic or private sector research institutions in
emerging proteome technologies through regular courses, talks and seminars
and a visiting scientist program.
Proteome Interest Group (PIG) is an internal seminar series
created to provide an educational resource for ISB staff and their
collaborators who have an interest in the application of proteomics
technologies. Though not open to the general scientific community,
collaborators may contact Julian
Watts, Ph.D., for more information about scheduled presentations. However, this
group is currently on hiatus.
SPIGOT is a local area interest group devoted to discussion,
development, and dissemination of proteomics software tools. The primary
goal of SPIGOT is to encourage open and collaborative software development
as an extension of the research being undertaken within ISB. By gathering
computational researchers from local institutions to meet on a regular basis,
we hope to productively address the common data analysis challenges facing
each of our proteomics facilities. As a forum to also disseminate software
tools developed within ISB, and to work directly with computational
counterparts in other organizations who will implement these tools in their
own environments, this will also be a forum to educate and train researchers
on the effective use of specific software tools. Past external participants
include researchers from the University of Washington, the Fred Hutch Cancer
Research Center, Amgen (formerly Immunex), and other Seattle-area companies.
This series is organized by Eric Deutsch.
Visiting scientist program - SPC offers the opportunity for outside
scientists to visit for extended periods of time for the purpose of performing
collaborative research and training in the field of proteomics related to
NHLBI-related projects. Due to limited space and resources, careful consideration
will be given to the selection of projects and investigators. Requests for
consideration of acceptance into this program should be directed to Rob Moritz.
The ISB has pioneered a new approach for quantitative protein profiling based on the ICAT regent technology
and tandem mass spectrometry. Such experiments typically lead to the acquisition of thousands to tens of
thousands of tandem mass spectra. The manual interpretation and validation of these data is no longer possible
and it is difficult to consistently interpret the information contained in proteomic profiles without the help
of suitable software tools. Therefore, the Center is also developing a suite of software tools that range
from the identification of peptides via sequence database searching of tandem mass spectra, the validation
of the search results using statistical principle, the organization of the data in a relational database to
the interpretation of proteomic data in the context of functional modules and biological pathways.
The ISB has adopted an open source software policy. To facilitate
dissemination of the tools, the ISB periodically offers a
course in proteomics-related software tools in which the principles behind
the tools and their use will be instructed. Each course participant will also
obtain copies of the tools for use in their institutions.